akkarilab

publications

books, papers, works, etc.

2020
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Mapping the Uncharted Territories of Human Brain Malignancies

2020
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Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

Science Translational Medicine, 15 Jul 2020: Vol. 12, Issue 552, eaaw7843

Leila AkkariRobert L BowmanJeremy TessierFlorian KlemmShanna M HandgraafMarnix de GrootDaniela F QuailLucie TillardJules GadiotJason T HuseDieta BrandsmaJohan WestergaColin WattsJohanna A Joyce 

2019
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Inducing and exploiting vulnerabilities for the treatment of liver cancer

Nature 574, 268–272 (2019)

Cun Wang, Serena Vegna, Haojie Jin, Bente Benedict, Cor Lieftink, Christel Ramirez, Rodrigo Leite de Oliveira, Ben Morris, Jules Gadiot, Wei Wang, Aimée du Chatinier, Liqin Wang, Dongmei Gao, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Arnout Schepers, Fleur Jochems, Antonio Mulero Sanchez, Sara Mainardi, Hein te Riele, Roderick L. Beijersbergen, Wenxin Qin, Leila Akkari & René Bernards 

2019
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The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

volume 178, issue 4, P807-819.E21, august 08, 2019

SanghviLeiboldMinaMohanBerishajLiMieleLaillerZhaode StanchinaVialeAkkariLoweCirielloHendricksonWendel

2017
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Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

Nature Cell Biology 19, 974–987 (2017)

Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari, Marsha L. Quick, I-Chun Chen, Nils Wendel, Nir Ben-Chetrit, Jeanne Walker, Peter R. Holt, Andrew J. Dannenberg & Johanna A. Joyce

2017
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Metabolic origins of spatial organization in the tumor microenvironment.

PNAS vol. 114 no. 11

Carmona-Fontaine C, Deforet M, Akkari L, Thompson CB, Joyce JA, Xavier JB. 

2016
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Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

Cell Reports vol. 17, issue 9

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.

2016
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TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Cell Reports vol. 16, issue 6

Anna Prudova5, Vasilena Gocheva5,8, Ulrich auf dem Keller5,7, Ulrich Eckhard5, Oakley C. Olson, Leila Akkari, Georgina S. Butler, Nikolaus Fortelny, Philipp F. Lange, Jennifer C. Mark, Johanna A. Joyce6,'Correspondence information about the author Johanna A. JoyceEmail the author Johanna A. Joyce, Christopher M. Overall

2016
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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Science Vol 352, Issue 6288 20 May 2016

Daniela F. Quail1, Robert L. Bowman1, Leila Akkari1,2,3, Marsha L. Quick1, Alberto J. Schuhmacher1, Jason T. Huse4, Eric C. Holland5, James C. Sutton6, Johanna A. Joyce1,2,3,*

2016
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Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer

Genes & Development 2016

Leila Akkari1,2,3,4, Vasilena Gocheva1,4, Marsha L. Quick1, Jemila C. Kester1, Alison K. Spencer1, Alfred L. Garfall1, Robert L. Bowman1 and Johanna A. Joyce1,2,3

2016
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High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system.

Leukemia & Lymphoma Volume 57, 2016 - Issue 8

Richard C. Curry, Geraldine Faivre, Leila Akkari, Johanna A. Joyce, Oscar Lin, Marc Rosenblum, Eli L. Diamond, Rebecca Fisher & Antonio Omuro

2014
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Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.

GENES & DEVELOPMENT 28:2134–2150

Leila Akkari, Vasilena Gocheva, Jemila C. Kester, Karen E. Hunter, Marsha L. Quick, Lisa Sevenich, Hao-Wei Wang, Christoph Peters, Laura H. Tang, David S. Klimstra, Thomas Reinheckel and Johanna A. Joyce

2013
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Emergence of spatial structure in the tumor microenvironment due to the Warburg effect

PNAS | November 26, 2013 | vol. 110 | no. 48 |

Carlos Carmona-Fontaine, Vanni Buccia, Leila Akkari , Maxime Deforet , Johanna A. Joyce , and Joao B. Xavier

2013
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mTOR regulates phagosome and entotic vacuole fission

Mol. Biol. Cell December 1, 2013 vol. 24 no. 23 3736-3745

Matej Krajcovic, Shefali Krishna, Leila Akkari, Johanna A. Joyce and Michael Overholtzer

2013
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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Nature Medicine 19, 1264–1272 (2013)

Stephanie M PyonteckLeila AkkariAlberto J SchuhmacherRobert L BowmanLisa SevenichDaniela F QuailOakley C OlsonMarsha L QuickJason T HuseVirginia TeijeiroManu SettyChristina S LeslieYoko OeiAlicia PedrazaJianan ZhangCameron W BrennanJames C SuttonEric C HollandDylan Daniel Johanna A Joyce

2013
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Modulation of Oxidative Stress by Twist Oncoproteins

PLOS ONE August 2013 | Volume 8 | Issue 8 |

Nicolas Floc’h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stephane Ansieau, Alain Puisieux, Urszula Hibner, Patrice Lassus

2013
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Non-cell-autonomous tumor suppression by p53.

Volume 153, Issue 2, p449–460, 11 April 2013

Amaia Lujambio, Leila Akkari, Janelle Simon, Danielle Grace, Darjus F. Tschaharganeh, Jessica E. Bolden, Zhen Zhao, Vishal Thapar, Johanna A. Joyce, Valery Krizhanovsky and Scott W. Lowe

2013
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Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis

PLOS Pathogens | 1 March 2013 | Volume 9 | Issue 3 |

Yannick Simonin, Serena Vegna, Leila Akkari, Damien Gregoire, Etienne Antoine, Jacques Piette, Nicolas Floch, Patrice Lassus, Guann-Yi Yu , Arielle R. Rosenberg , Michael Karin , David Durantel, Urszula Hibner

2012
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Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors

Journal of Hepatology, November 2012, Volume 57, Issue 5, p935-1160

Leila Akkari, Damien Grégoire, Nicolas Floch, Marie Moreau, Céline Hernandez, Yannick Simonin, Arielle R. Rosenberg, Patrice Lassus, Urszula Hibner 

2010
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Cell shape and TGF-β signaling define the choice of lineage during in vitro differentiation of mouse primary hepatic precursors

Journal of Cellular Physiology, Volume 225, Issue 1, October 2010, p186–195

Leila Akkari, Delphine Haouzi, Fabien Binamé, Nicolas Floch, Patrice Lassus, Stephen Baghdiguian, Urszula Hibner