Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play.
Johanna Erbani Menno Boon Leila Akkari
Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells
Charles P Couturier, Javad Nadaf, Zhaorong Li, Salma Baig, Gabriele Riva, Phuong Le, Daan J Kloosterman, Jean Monlong, Andriniaina Nkili Meyong, Redouane Allache, Theresa Degenhard, Mariam Al-Rashid, Marie-Christine Guiot, Guillaume Bourque, Jiannis Ragoussis, Leila Akkari, Francisco J Quintana, Kevin Petrecca
Early Therapeutic Interventions for Newly Diagnosed Glioblastoma: Rationale and Review of the Literature
Mueez Waqar, Daniel M. Trifiletti, Catherine McBain, James O’Connor, David J. Coope, Leila Akkari, Alfredo Quinones-Hinojosa & Gerben R. Borst
EGFR activation limits the response of liver cancer to lenvatinib
Haojie Jin, Yaoping Shi, Yuanyuan Lv, Shengxian Yuan, Christel F. A. Ramirez, Cor Lieftink, Liqin Wang, Siying Wang, Cun Wang, Matheus Henrique Dias, Fleur Jochems, Yuan Yang, Astrid Bosma, E. Marielle Hijmans, Marnix H. P. de Groot, Serena Vegna, Dan Cui, Yangyang Zhou, Jing Ling, Hui Wang, Yuchen Guo, Xingling Zheng, Nikita Isima, Haiqiu Wu, Chong Sun, Roderick L. Beijersbergen, Leila Akkari, Weiping Zhou, Bo Zhai, Wenxin Qin & René Bernards
Mapping the Uncharted Territories of Human Brain Malignancies
Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Cun Wang, Serena Vegna, Haojie Jin, Bente Benedict, Cor Lieftink, Christel Ramirez, Rodrigo Leite de Oliveira, Ben Morris, Jules Gadiot, Wei Wang, Aimée du Chatinier, Liqin Wang, Dongmei Gao, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Arnout Schepers, Fleur Jochems, Antonio Mulero Sanchez, Sara Mainardi, Hein te Riele, Roderick L. Beijersbergen, Wenxin Qin, Leila Akkari & René Bernards
Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers
Karoline Kielbassa, Serena Vegna, Christel Ramirez and Leila Akkari
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Sanghvi, Leibold, Mina, Mohan, Berishaj, Li, Miele, Lailler, Zhao, de Stanchina, Viale, Akkari, Lowe, Ciriello, Hendrickson, Wendel
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
D Yan, J Kowal, L Akkari, AJ Schuhmacher, JT Huse, BL West and JA Joyce
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari, Marsha L. Quick, I-Chun Chen, Nils Wendel, Nir Ben-Chetrit, Jeanne Walker, Peter R. Holt, Andrew J. Dannenberg & Johanna A. Joyce
Metabolic origins of spatial organization in the tumor microenvironment.
Carmona-Fontaine C, Deforet M, Akkari L, Thompson CB, Joyce JA, Xavier JB.
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.
TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Anna Prudova5, Vasilena Gocheva5,8, Ulrich auf dem Keller5,7, Ulrich Eckhard5, Oakley C. Olson, Leila Akkari, Georgina S. Butler, Nikolaus Fortelny, Philipp F. Lange, Jennifer C. Mark, Johanna A. Joyce6,'Correspondence information about the author Johanna A. JoyceEmail the author Johanna A. Joyce, Christopher M. Overall
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Daniela F. Quail1, Robert L. Bowman1, Leila Akkari1,2,3, Marsha L. Quick1, Alberto J. Schuhmacher1, Jason T. Huse4, Eric C. Holland5, James C. Sutton6, Johanna A. Joyce1,2,3,*
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
Leila Akkari1,2,3,4, Vasilena Gocheva1,4, Marsha L. Quick1, Jemila C. Kester1, Alison K. Spencer1, Alfred L. Garfall1, Robert L. Bowman1 and Johanna A. Joyce1,2,3
High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system.
Richard C. Curry, Geraldine Faivre, Leila Akkari, Johanna A. Joyce, Oscar Lin, Marc Rosenblum, Eli L. Diamond, Rebecca Fisher & Antonio Omuro
Reply to: "arginase 1: a potential marker of a common pattern of liver steatosis in HCV and NAFLD children"
Eric Assenat, Leila Akkari, Marie Moreau, Urszula Hibner
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Leila Akkari, Vasilena Gocheva, Jemila C. Kester, Karen E. Hunter, Marsha L. Quick, Lisa Sevenich, Hao-Wei Wang, Christoph Peters, Laura H. Tang, David S. Klimstra, Thomas Reinheckel and Johanna A. Joyce
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
Carlos Carmona-Fontaine, Vanni Buccia, Leila Akkari , Maxime Deforet , Johanna A. Joyce , and Joao B. Xavier
mTOR regulates phagosome and entotic vacuole fission
Matej Krajcovic, Shefali Krishna, Leila Akkari, Johanna A. Joyce and Michael Overholtzer
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Stephanie M Pyonteck, Leila Akkari, Alberto J Schuhmacher, Robert L Bowman, Lisa Sevenich, Daniela F Quail, Oakley C Olson, Marsha L Quick, Jason T Huse, Virginia Teijeiro, Manu Setty, Christina S Leslie, Yoko Oei, Alicia Pedraza, Jianan Zhang, Cameron W Brennan, James C Sutton, Eric C Holland, Dylan Daniel & Johanna A Joyce
Modulation of Oxidative Stress by Twist Oncoproteins
Nicolas Floc’h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stephane Ansieau, Alain Puisieux, Urszula Hibner, Patrice Lassus
Non-cell-autonomous tumor suppression by p53.
Amaia Lujambio, Leila Akkari, Janelle Simon, Danielle Grace, Darjus F. Tschaharganeh, Jessica E. Bolden, Zhen Zhao, Vishal Thapar, Johanna A. Joyce, Valery Krizhanovsky and Scott W. Lowe
Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis
Yannick Simonin, Serena Vegna, Leila Akkari, Damien Gregoire, Etienne Antoine, Jacques Piette, Nicolas Floch, Patrice Lassus, Guann-Yi Yu , Arielle R. Rosenberg , Michael Karin , David Durantel, Urszula Hibner
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors
Leila Akkari, Damien Grégoire, Nicolas Floch, Marie Moreau, Céline Hernandez, Yannick Simonin, Arielle R. Rosenberg, Patrice Lassus, Urszula Hibner
Cell shape and TGF-β signaling define the choice of lineage during in vitro differentiation of mouse primary hepatic precursors
Leila Akkari, Delphine Haouzi, Fabien Binamé, Nicolas Floch, Patrice Lassus, Stephen Baghdiguian, Urszula Hibner