Characterize the tumor microenvironment dynamics in hepatocellular carcinoma (HCC) initiation and progression.
The liver is unique per its capacity to regenerate, and its highly immune-tolerant functions. Kupffer cells (KCs), the tissue resident macrophages of the liver, are critical to maintain liver homeostasis and to promote hepatocyte proliferation during
Investigating the microenvironmental regulation of glioma recurrence
Not all cells are equally malignant in gliomas. Certain subpopulations are particularly prone to drive resistance and recurrence to chemo- and radiotherapy, through multiple molecular mechanisms including activation of the DNA damage checkpoints or N
Targeting myeloid cells during glioma therapeutic response to standard of care therapy
The consequences of cancer cell death induced by radio or chemotherapy include the release of endogenous immune adjuvants in the tumor microenvironment (TME) that may influence macrophage activation status and their recruitment to the tumor site. Rec